Breast cancer can make anyone feel alone. The American Cancer Society supports people as they fight breast cancer by providing 24/7 phone support, rides to treatment, places to stay during treatment, or even just a hand to hold. Together, we are
stronger than breast cancer.
American Cancer Society Denim Day is October 7, 2016.
The American Cancer Society Denim Day – Oct 7, 2016 – brings us together to help save more lives from breast cancer. Since the event’s beginning in 1996, participants have raised more than $95 million to make sure no one has to face breast cancer alone.
This year more than 200,000 American women are expected to be diagnosed with breast cancer. With deaths from the disease among women ranking second only to lung cancer, we must continue to make progress. The American Cancer Society issues breast
cancer screening guidelines, funds research for improved screening and treatment, encourages healthy lifestyles that can help prevent a diagnosis, and provides services for all who face the disease.
Our mission is to help free the world from the
pain and suffering of breast cancer – and every cancer.
Your Denim Day donations will help us save more lives from breast cancer. We do the most for people with breast cancer today, to end the disease tomorrow.
In fact, mortality rates from breast cancer have dropped 36% since 1989. That’s 249,000 lives saved! Your support will help make it possible to end breast cancer once and for all.
Research to Find Causes, Better Treatments,
and Cures for Breast Cancer The American Cancer Society has invested more than $4.5 billion in cancer research since 1946 and has played a role in nearly every cancer research breakthrough in recent history. In 2016, we continue to use donations from Denim Day to help fund breast cancer research, programs, and services. To find out more about projects we fund and breast cancer research news, click here.
American Cancer Society DENIM DAY GRANT PROFILE SUMMARY
Hiroyuki Inuzuka, PhD
Regulation of Skp2 Oncogenic Functions by Acetylation in Breast Cancer
Beth Israel Deaconess Medical Center
Breast cancer is the most common female malignancy, and the second leading cause of cancer-related death after lung cancer in the United States. Although surgical intervention, treatments, and prognoses have improved over the past decade,
we are not where we’d like to be in terms of an effective cure for patients suffering from advanced disease. The long-term goal of this study is to define the signals involved in breast tumor malignancies, and to establish their potentials as
novel anti-tumor strategies.
Specifically, this study focuses on the oncoprotein, Skp2, which is critical for degrading other proteins, most notably a number of tumor suppressor proteins. Dr. Hiroyuki Inuzuka recently discovered that a separate protein – one that’s
associated with estrogen activation of breast cancer – modifies Skp2, and this leads to aggressive tumor progression in animal models. Understanding how this modification affects the action of Skp2 and how it might be reversed is the goal of this
work. Since Skp2-specific inhibitors are not currently available in clinical practice, targeting the control of Skp2 activity is a logical means to treating breast cancers.
In summary, a better understanding of the regulatory mechanisms of Skp2 will benefit basic cancer research, clinical diagnosis, and therapy for breast cancers.
The American Cancer Society Denim Day brings people together to help free the world from the pain and suffering of breast cancer.
In the weeks leading up to Denim Day, rally your friends and coworkers to donate $5 or more to wear jeans to work on Friday, October 7. Money raised will support the American Cancer Society’s mission to save lives from breast
Since Denim Day began in 1996, participants have raised more than $95 million to help save lives from breast cancer.
This year, by joining together, we’ll add even more to that total. Donations will help the American Cancer Society fund groundbreaking breast cancer research; provide free, comprehensive information and support to those touched by breast cancer;
and help people take steps to reduce their breast cancer risk or find it early when it's most treatable.
History of Denim Day
Denim Day began with a simple concept – if each of us takes a small step to help eliminate breast cancer, collectively, those steps will take us far in achieving our goal. Employees at a private company got together to ask coworkers for donations
to “go casual” for the cause. And what’s more casual than denim?
The idea spread, and now companies, schools, and other organizations nationwide have participated in raising funds and awareness to support our programs and services that help those with breast cancer, and also to help others avoid a diagnosis