BENEFITING: The Chadtough Foundation
EVENT DATE: Mar 08, 2018
"I am a physician-scientist working at the University of Michigan Medical Center. I am a neuropathologist and my laboratory works on understanding the biology of DIPG in order to develop a cure for this lethal tumor. I was born in India and trained at the University of Pittsburgh, University of Pennsylvania and Memorial Sloan Kettering Cancer Center. I moved to Ann Arbor to start my clinical work and research laboratory on childhood brain tumors in November 2014 at the University of Michigan.
"While at Memorial Sloan Kettering Cancer Center, I discovered a critical clue that helps us understand the pathology of DIPG cancers by examining changes in a mutant protein around which DNA is packed in the nucleus of DIPG cancer cells. I developed a clinical test based on this work that was adopted by the World Health Organization and is now routinely used to diagnose DIPGs around the world. My laboratory studies how this protein causes DIPG cancers to occur and how DIPG cancer cells fuel growth by devouring nutrients from the brain. Our goal is to develop drugs that will kill DIPG cancer cells by targeting this protein and preventing them from consuming fuels. My laboratory also works and collaborates closely with Dr. Carl Koschmann's laboratory at the University of Michigan to combat DIPGs.
"I am constantly inspired and motivated by children and their families who lives have been devastated by DIPG. We are extremely appreciative and grateful to Tammi, Jason, Lloyd and many other families that believe in this cause and support DIPG research by donating their valuable resources and time. I also wanted to thank families including the Carrs for brain donations that enable us research DIPGs. You are with us in the laboratory everyday as we unravel this deadly tumor one step at a time and march ahead to cure DIPG!"