This is a truly unique challenge - the 10km race through the Ethiopian capital, Addis Ababa, attracts most of its support locally, with less than 800 competitors traveling to the event from outside the country. Addis is the fifth highest capital city in the world - at an altitude of 7,726 feet - so there's an extra challenge in the race for new visitors to the city.
This will be the third year in which Self Help Africa has organized a team in the race, and up to 15 people will travel from New York to compete and raise funds for Self Help Africa's work in Ethiopia.
Self Help Africa first began working in Ethiopia in 1984, in the wake of that country's Great Famine, to help increase harvests on farms around the country.
Almost 30 years later, the non-profit organization continues to work with rural communities across Ethiopia - as well as in eight other countries across Africa - helping the rural poor to start small businesses, increase profits and lift themselves out of poverty.
Last year, Self Help Africa spent almost $13m on these programs, helping over 900,000 people.
All funds raised by the US team in the event will be used to support Self Help Africa.