Less Cancer Board Member he served as CNNs chief technology and environment correspondent. He was also the network’s space and aviation correspondent and an occasional stand-in anchor.
During his 16-year tenure at CNN, he anchored several news and talk programs, including Science and Technology Week, Saturday Morning, Sunday Morning, Talk Back LIve Headline News, Prime Time, and, most recently, American Morning.
It was announced on December 3, 2008 that O'Brien would be leaving CNN, along with 6 producers, as a result of the company disbanding most of its science and technology unit.
In 2009 Miles joined PBS working on Blueprint America that deals with rebuilding America infrastructure where the redirection of focus from the auto to high-speed rail and other mass transit options.
On October 15, 2009, Miles made an appearance on Fox Business News covering the breaking news story of the Colorado runaway mylar helium balloon with a supposedly trapped child inside the balloon.
On October 27, 2009, Miles publicly announced that he has been made a member of the NASA Advisory Council (NAC) as the Chairman of the Education and Outreach Committee.
In February 2010, he worked on the Frontline documentary, "Flying Cheap" which aired on the 1 year anniversary of the Colgan Air plane crash in Buffalo, NY. The highly acclaimed documentary featured former Colgan Air pilots revealing shocking details about some attempts to keep underpaid pilots flying beyond legal limits.
In late September 2010, Miles joined PBS NEWS HOUR as a science correspondent.
O'Brien is on the board of the Next Generation Choices Foundation and the Less Cancer Campaign.
- 1986 – Florida Emmy Award “Outstanding Coverage of a Single Breaking News Story” (Reporter) St. Petersburg Chlorine Leak
- 1989 – Boston/New England Emmy Award “Outstanding News Series” (Producer/Reporter) Boundaries of Fear
- 1990 – CINE “Golden Eagle” (Producer/Reporter) Boundaries of Fear
- 1993 – Computer Press Awards “Best Television Program” (Anchor/Correspondent/Writer) CNN Science and Technology Week
- 1993 – National Association of Science Writers “Science in Society Award” (Anchor/Correspondent/Writer) Sweet Fruit – Bitter Harvest.
- 1996 – News and Documentary Emmy Award “Outstanding Coverage of a Single breaking News Story” (Anchor) Coverage of the Olympic Park Bombing
- 2002 – Rotary National Award for Space Achievement “Space Communicator Award”
- 2002 – National Space Club “Media Award”
- 2006 – Society of Environmental Journalists “Award for Reporting on the Environment (Anchor/Correspondent/Writer) CNN Presents: Melting Point
- 2006 – National Press Club “Robert L Kozik Award for Environmental Reporting – First Place” (Anchor/Correspondent/Writer) CNN Presents: Melting Point
- 2006 – Aircraft Owners and Pilots Association “Max Karant Award for Excellence in General Aviation Journalism” (Correspondent) Small Planes
- 2006 – George Foster Peabody, Alfred I. duPont-Columbia University and News and Documentary Emmy Awards (Anchor/Correspondent) CNN Coverage of Hurricane Katrina and Aftermath CNN
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