Rett Syndrome is the most physically disabling of the autism spectrum disorders, primarily affecting girls, and usually strikes by 18 months of age. It is caused by mutations on the X chromosome on a gene. As the cascade of Rett Symptoms descends, a child loses acquired skills, normal movement and speech, then begins the long regression that may leave her in a wheelchair, unable to communicate or use her hands. Extreme anxiety, Parkinson-like tremors, seizures and orthopedic problems are common.
In 2007 Rett Syndrome was reversed in a mouse model. Since then, Rett Syndrome has peaked the interest of many researchers all over the world. There is no grant money going towards Rett Syndrome research, and the only money that is funding the researchers for a cure is privately funded.