The Upside-Down Children with Down syndrome and Cancer Holiday Drive raises funds to help families challenged by a diagnosis of Down syndrome and cancer. When cancer strikes a child with Down syndrome, it is often initially misdiagnosed. The Upside Down fund teaches parents and caregivers to look for signs and symptoms of cancer in a child who has Down syndrome. These children may not be verbal enough to tell someone what is happening. The diagnosis of childhood cancer puts a financial strain on families. The Upside Down Fund offers critical financial assistance to families throughout treatment, which typically takes several years. The entire family suffers when a family member with Down syndrome is diagnosed with cancer, so the Upside Down Fund offers support to the entire family, from hospital care kits for patients and caregivers, sibling care packages, information for grandparents and friends and individualized plans for each family. Up to 10% of newborns with Down syndrome are born with transient myeloproliferative disorder (TMD) also called transient leukemia. About 30% of these children will develop Acute Myelocytic leukemia. Approximately 1 in 95 children with Down syndrome will develop leukemia, usually in the first decade of life. The good news is that these children most often survive. But, during treatment and after, families need help. Treatment can cause life-long challenges. Please support the Upside Down Children with Down syndrome and Cancer and lighten the load on a family who really needs your help. The fund is run by Wisconsin Upside Down and benefits families all over Wisconsin. We also provide training to Down syndrome organizations outside of Wisconsin to help them help other families facing this same diagnosis.